Jacob Bethell will miss the entirety of England's upcoming Test series against Pakistan, while Ollie Pope and Brydon Carse have been named in the 16-man squad.
England are preparing to return to action following their series defeat to New Zealand and the departures of head coach Brendon McCullum and captain Ben Stokes.
Joe Root, reinstalled as skipper following Stokes' international retirement, will lead a team seeking to turn the page on a difficult spell on and off the field. The three-match series begins at Headingley on August 19, live on Sky Sports Cricket.
Bethell sustained a knee injury during England's ODI series against India in July, causing him to miss The Hundred.
He will remain sidelined for the Pakistan series, with Essex wicketkeeper Jordan Cox replacing him at No 3 having made his Test debut earlier this summer.
Pope, formerly vice captain under Stokes, and Carse return to the Test squad for the first time since England's dismal Ashes tour of Australia last winter.
Dan Lawrence has also been recalled to the side two years after his last Test appearance and is set to enter the starting XI to bat at No 6.
England squad to face Pakistan
England vs Pakistan (Test cricket) - August and September
Watch the three-Test series between England and Pakistan live on Sky Sports Cricket from August 19. Stream cricket and more sport contract-free with NOW.
England's shake-up follows a difficult period that also includes the end of the Brendon McCullum and Ben Stokes era in the roles of head coach and captain. Joe Root now takes charge again, with the side looking to reset when Pakistan arrive at Headingley.
